MFI 5000 Series Flow Microscopes

The MFI 5000 series of imaging‐based particle counters are designed to address the US FDA's requirement to characterize and quantify aggregates and particulates in biotherapeutics.  Yielding consistent, precise and repeatable results, MFI 5000 systems allow users to optimize and monitor their formulations with novel and unique characterization metrics. When integrated with the Bot1 high throughput autosampler the MFI5000 series dramatically reduces operator hands-on time while increasing sample throughput. Automated sample delivery ensures consistency streamlining the particle analysis process.

Features:

• Individually images, counts and sizes particles in liquid formulations
• Optimized detection sensitivity for translucent particles
• Qualified for cGMP applications
• Automated sample introduction and analysis 
• Automated system flushing/cleaning, focus and verification
• Unattended overnight operation

Typical Applications:

• Address US FDA requirements for subvisible particle analysis
• Optimize mAb formulations to minimize subvisible particle formation
• Characterize and quantify particles after reconstituting lyophilized samples
• Distinguish silicone oil droplets from aggregates
• Investigate aggregates and particulates in vaccine development
• Monitor and control process variables contributing to particle formation

Download the MFI 5000 brochure and the Bot1 brochure for detailed specifications.

• Bot1 Brochure
• MFI 5000 Flow Microscope Brochure